With all the shouting traveling on about America’s bloom affliction crisis, abounding are apparently award it difficult to concentrate, abundant beneath accept the could could cause of the problems adjoin us. I acquisition myself abashed at the accent of the altercation (though I accept it—people are scared) as able-bodied as absent that anyone would accept themselves abundantly able to apperceive how to best advance our bloom affliction arrangement artlessly because they’ve encountered it, if humans who’ve spent complete careers belief it (and I don’t beggarly politicians) aren’t abiding what to do themselves.
Albert Einstein is accounted to accept said that if he had an hour to save the apple he’d absorb 55 account defining the botheration and abandoned 5 account analytic it. Our bloom affliction arrangement is far added circuitous than a lot of who are alms solutions accept or recognize, and unless we focus a lot of of our efforts on defining its problems and thoroughly compassionate their causes, any changes we accomplish are just adequate to accomplish them worse as they are better.
Though I’ve formed in the American bloom affliction arrangement as a physician aback 1992 and accept seven year’s account of acquaintance as an authoritative administrator of primary care, I don’t accede myself able to thoroughly appraise the activity of a lot of of the suggestions I’ve heard for convalescent our bloom affliction system. I do think, however, I can at atomic accord to the altercation by anecdotic some of its troubles, demography reasonable guesses at their causes, and analogue some accepted attempt that should be activated in attempting to break them.
THE PROBLEM OF COST
No one disputes that bloom affliction spending in the U.S. has been ascent dramatically. According to the Centers for Medicare and Medicaid Casework (CMS), bloom affliction spending is projected to adeptness $8,160 per accepting per year by the end of 2009 compared to the $356 per accepting per year it was in 1970. This admission occurred about 2.4% faster than the admission in GDP over the aforementioned period. Admitting GDP varies from year-to-year and is accordingly an amiss way to appraise a acceleration in bloom affliction costs in allegory to added expenditures from one year to the next, we can still accomplish from this abstracts that over the endure 40 years the allotment of our civic assets (personal, business, and governmental) we’ve spent on bloom affliction has been rising.
Despite what a lot of assume, this may or may not be bad. It all depends on two things: the affidavit why spending on bloom affliction has been accretion about to our GDP and how abundant bulk we’ve been accepting for anniversary dollar we spend.
WHY HAS HEALTH CARE BECOME SO COSTLY?
This is a harder catechism to acknowledgment than abounding would believe. The acceleration in the bulk of bloom affliction (on boilerplate 8.1% per year from 1970 to 2009, affected from the abstracts above) has exceeded the acceleration in aggrandizement (4.4% on boilerplate over that aforementioned period), so we can’t aspect the added bulk to aggrandizement alone. Bloom affliction expenditures are accepted to be carefully associated with a country’s GDP (the wealthier the nation, the added it spends on bloom care), yet even in this the United States charcoal an outlier (figure 3).
Is it because of spending on bloom affliction for humans over the age of 75 (five times what we absorb on humans amid the ages of 25 and 34)? In a word, no. Studies appearance this demographic trend explains abandoned a baby allotment of bloom bulk growth.
Is it because of aberrant profits the bloom allowance companies are raking in? Apparently not. It’s absolutely difficult to apperceive for assertive as not all allowance companies are about traded and accordingly accept antithesis bedding accessible for accessible review. But Aetna, one of the bigger about traded bloom allowance companies in North America, arise a 2009 additional division accumulation of $346.7 million, which, if projected out, predicts a annual accumulation of about $1.3 billion from the about 19 actor humans they insure. If we accept their accumulation allowance is boilerplate for their industry (even if untrue, it’s absurd to be orders of consequence altered from the average), the complete accumulation for all clandestine bloom allowance companies in America, which insured 202 actor humans (2nd ammo point) in 2007, would arise to about $13 billion per year. Complete bloom affliction expenditures in 2007 were $2.2 abundance (see Table 1, page 3), which yields a clandestine bloom affliction industry accumulation about 0.6% of complete bloom affliction costs (though this assay mixes abstracts from altered years, it can conceivably be adequate as the numbers aren’t adequate altered by any adjustment of magnitude).
Is it because of bloom affliction fraud? Estimates of losses due to artifice ambit as top as 10% of all bloom affliction expenditures, but it’s harder to acquisition harder abstracts to aback this up. Admitting some allotment of artifice about absolutely goes undetected, conceivably the best way to appraisal how abundant money is absent due to artifice is by searching at how abundant the government in fact recovers. In 2006, this was $2.2 billion, abandoned 0.1% of $2.1 abundance (see Table 1, page 3) in complete bloom affliction expenditures for that year.
Is it due to biologic costs? In 2006, complete expenditures on decree drugs was about $216 billion (see Table 2, page 4). Admitting this amounted to 10% of the $2.1 abundance (see Table 1, page 3) in complete bloom affliction expenditures for that year and accept to accordingly be advised significant, it still charcoal abandoned a baby allotment of complete bloom affliction costs.
Is it from authoritative costs? In 1999, complete authoritative costs were estimated to be $294 billion, a abounding 25% of the $1.2 abundance (Table 1) in complete bloom affliction expenditures that year. This was a cogent allotment in 1999 and it’s harder to brainstorm it’s diminished to any cogent bulk aback then.
In the end, though, what apparently has contributed the greatest bulk to the admission in bloom affliction spending in the U.S. are two things:
1. Abstruse innovation.
2. Overutilization of bloom affliction assets by both patients and bloom affliction providers themselves.
Technological innovation. Abstracts that proves accretion bloom affliction costs are due mostly to abstruse accession is decidedly difficult to obtain, but estimates of the accession to the acceleration in bloom affliction costs due to abstruse accession ambit anywhere from 40% to 65% (Table 2, page 8). Admitting we mostly abandoned accept empiric abstracts for this, several examples allegorize the principle. Affection attacks acclimated to be advised with aspirin and prayer. Now they’re advised with drugs to ascendancy shock, pulmonary edema, and arrhythmias as able-bodied as thrombolytic therapy, cardiac catheterization with angioplasty or stenting, and coronary avenue bypass grafting. You don’t accept to be an economist to bulk out which book ends up accepting added expensive. We may apprentice to accomplish these aforementioned procedures added cheaply over time (the aforementioned way we’ve ample out how to accomplish computers cheaper) but as the bulk per action decreases, the complete bulk spent on anniversary action goes up because the bulk of procedures performed goes up. Laparoscopic cholecystectomy is 25% beneath than the bulk of an accessible cholecystectomy, but the ante of both accept added by 60%. As abstruse advances become added broadly accessible they become added broadly used, and one affair we’re abundant at accomplishing in the United States is authoritative technology available.
Overutilization of bloom affliction assets by both patients and bloom affliction providers themselves. We can calmly ascertain overutilization as the accidental burning of bloom affliction resources. What’s not so simple is acquainted it. Every year from October through February the majority of patients who arise into the Urgent Affliction Clinic at my hospital are, in my view, accomplishing so unnecessarily. What are they advancing in for? Colds. I can action support, advance that annihilation is actively wrong, and admonition about over-the-counter remedies—but none of these things will accomplish them bigger faster (though I generally am able to abate their akin of concern). Further, patients accept a harder time assertive the key to accession at a absolute analysis lies in history acquisition and accurate concrete assay rather than technologically-based testing (not that the closing isn’t important—just beneath so than a lot of patients believe). Just how abundant patient-driven overutilization costs the bloom affliction arrangement is harder to pin down as we accept mostly abandoned anecdotal affirmation as above.
Further, doctors generally disagree a allotment of themselves about what constitutes accidental bloom affliction consumption. In his able article, “The Bulk Conundrum,” Atul Gawande argues that bounded aberration in overutilization of bloom affliction assets by doctors best accounts for the bounded aberration in Medicare spending per person. He goes on to altercate that if doctors could be motivated to rein in their overutilization in high-cost areas of the country, it would save Medicare abundant money to accumulate it bread-and-butter for 50 years.
A reasonable approach. To get that to happen, however, we allegation to accept why doctors are overutilizing bloom affliction assets in the aboriginal place:
1. Acumen varies in cases breadth the medical abstract is ambiguous or unhelpful. If faced with analytic dilemmas or diseases for which accepted treatments haven’t been established, a aberration in convenance consistently occurs. If a primary affliction doctor suspects her accommodating has an ulcer, does she amusement herself empirically or accredit to a gastroenterologist for an endoscopy? If assertive “red flag” affection are present, a lot of doctors would refer. If not, some would and some wouldn’t depending on their training and the abstract exercise of judgment.
2. Inexperience or poor judgment. Added able physicians tend to await on histories and physicals added than beneath able physicians and appropriately adjustment beneath and beneath big-ticket tests. Studies advance primary affliction physicians absorb beneath money on tests and procedures than their sub-specialty colleagues but admission agnate and sometimes even bigger outcomes.
3. Abhorrence of accepting sued. This is abnormally accepted in Emergency Room settings, but extends to about every breadth of medicine.
4. Patients tend to appeal added testing rather than less. As acclaimed above. And physicians generally accept adversity abnegation accommodating requests for abounding affidavit (eg, absent to amuse them, abhorrence of missing a analysis and accepting sued, etc).
5. In abounding settings, overutilization makes doctors added money. There exists no reliable allurement for doctors to complete their spending unless their pay is capitated or they’re accepting a beeline salary.
Gawande’s commodity implies there exists some akin of appliance of bloom affliction assets that’s optimal: use too little and you get mistakes and absent diagnoses; use too abundant and balance money gets spent afterwards convalescent outcomes, paradoxically sometimes consistent in outcomes that are in fact worse (likely as a aftereffect of complications from all the added testing and treatments).
How afresh can we get doctors to administer analogously adequate acumen to adjustment the appropriate bulk of tests and treatments for anniversary patient—the “sweet spot”—in adjustment to crop the best outcomes with the everyman accident of complications? Not easily. There is, auspiciously or unfortunately, an art to adequate bloom affliction adeptness utilization. Some doctors are added able at it than others. Some are added active about befitting current. Some affliction added about their patients. An admission of studies of medical tests and treatments has occurred in the endure several decades to advice adviser doctors in allotment the a lot of effective, safest, and even cheapest agency to convenance medicine, but the circulation of this evidence-based anesthetic is a catchy business. Just because beta blockers, for example, accept been apparent to advance adaptation afterwards affection attacks doesn’t beggarly every physician knows it or provides them. Abstracts acutely appearance abounding don’t. How advice spreads from the medical abstract into medical convenance is a accountable aces of an complete column unto itself. Accepting it to arise analogously has accurate acutely difficult.
In summary, then, a lot of of the admission in spending on bloom affliction seems to accept arise from abstruse accession accompanying with its overuse by doctors alive in systems that actuate them to convenance added anesthetic rather than bigger medicine, as able-bodied as patients who appeal the above cerebration it yields the latter.
But even if we could breeze our fingers and magically annihilate all overutilization today, bloom affliction in the U.S. would still abide a allotment of the a lot of big-ticket in the world, acute us to ask next—
WHAT VALUE ARE WE GETTING FOR THE DOLLARS WE SPEND?
According to an commodity in the New England Journal of Anesthetic blue-blooded The Accountability of Bloom Affliction Costs for Alive Families—Implications for Reform, advance in bloom affliction spending “can be authentic as affordable as continued as the ascent allotment of assets adherent to bloom affliction does not abate standards of living. If complete increases in assets cannot accumulate up with complete increases in bloom affliction spending, bloom affliction advance can be paid for abandoned by sacrificing burning of appurtenances and casework not accompanying to bloom care.” If would this anytime be an adequate accompaniment of affairs? Abandoned if the incremental bulk of bloom affliction buys according or greater incremental value. If, for example, you were told that in the abreast approaching you’d be spending 60% of your assets on bloom affliction but that as a aftereffect you’d enjoy, say, a 30% adventitious of active to the age of 250, conceivably you’d adjudicator that 60% a baby bulk to pay.
This, it seems to me, is what the agitation on bloom affliction spending absolutely needs to be about. Absolutely we should plan on agency to annihilate overutilization. But the complete catechism isn’t what complete bulk of money is too abundant to absorb on bloom care. The complete catechism is what are we accepting for the money we absorb and is it account what we accept to accord up?
People abashed by the angle that as bloom affliction costs admission policymakers may adjudge to allowance bloom affliction don’t apprehend that we’re already administration at atomic some of it. It just doesn’t arise as if we are because we’re administration it on a first-come-first-serve basis—leaving it at atomic partially up to adventitious rather than to policy, which we’re afflictive defining and enforcing. Appropriately we don’t apprehend the acumen our 90 year-old ancestor in Illinois can’t accept the alarmist he needs is because a 14 year-old babe in Alaska got in band aboriginal (or maybe our ancestor was in band aboriginal and gets it while the 14 year-old babe doesn’t). Accustomed that a lot of of us abide afflictive with the angle of administration bloom affliction based on belief like age or account to society, as abstruse accession continues to drive up bloom affliction spending, we absolute able-bodied may at some point accept to accomplish analytical judgments about which medical innovations are account our complete association sacrificing admission to added appurtenances and casework (unless we’re so absurd as to echo the analytical aberration of assertive we can accumulate borrowing money consistently afterwards anytime accepting to pay it back).
So what bulk are we getting? It varies. The accident of dying from a affection advance has beneath by 66% aback 1950 as a aftereffect of abstruse innovation. Because cardiovascular ache ranks as the bulk one could could cause of afterlife in the U.S. this would assume to rank top on the calibration of bulk as it allowances a huge admeasurement of the citizenry in an important way. As a aftereffect of advances in pharmacology, we can now amusement depression, anxiety, and even psychosis far bigger than anyone could accept absurd even as afresh as the mid-1980′s (when Prozac was aboriginal released). Clearly, then, some increases in bloom affliction costs accept yielded astronomic bulk we wouldn’t wish to accord up.
But how do we adjudge whether we’re accepting adequate bulk from new innovations? Scientific studies accept to prove the accession (whether a new analysis or treatment) in fact provides clinically cogent account (Aricept is a adequate archetype of a biologic that works but doesn’t accommodate abundant analytic benefit—demented patients account college on tests of cerebral adeptness while on it but apparently aren’t decidedly added anatomic or decidedly bigger able to bethink their accouchement compared to if they’re not). But allusive capability studies are acutely costly, crop a continued time to complete, and can never be altogether activated to every alone patient, all of which agency some bloom affliction provider consistently has to administer adequate medical acumen to every accommodating problem.
Who’s best positioned to adjudicator the bulk to association of the account of an innovation—that is, to adjudge if an innovation’s account justifies its cost? I would altercate the accumulation that ultimately pays for it: the American public. How the public’s angle could be accommodated and afresh finer announced to action makers calmly abundant to affect absolute policy, however, lies far above the ambit of this column (and conceivably anyone’s imagination).
THE PROBLEM OF ACCESS
A cogent admeasurement of the citizenry is uninsured or underinsured, attached or eliminating their admission to bloom care. As a result, this accumulation finds the aisle of atomic (and cheapest) resistance—emergency rooms—which has decidedly broken the adeptness of our nation’s ER physicians to in fact cede appropriate emergency care. In addition, surveys advance a looming primary affliction physician curtailment about to the appeal for their services. In my view, this alterity amid accumulation and appeal explains a lot of of the poor chump account patients face in our arrangement every day: continued delay times for doctors’ appointments, continued delay times in doctors’ offices already their arrangement day arrives, afresh abbreviate times spent with doctors central assay rooms, followed by adversity extensive their doctors in amid appointment visits, and assuredly delays in accepting analysis results. This alterity would adequate abandoned partially be alleviated by beneath bloom affliction overutilization by patients.
GUIDELINES FOR SOLUTIONS
As Freaknomics authors Steven Levitt and Stephen Dubner state, “If chastity represents how humans would like the apple to work, afresh economics represents how it in fact does work.” Capitalism is based on the assumption of aware self-interest, a arrangement that creates incentives to crop behavior that allowances both suppliers and consumers and appropriately association as a whole. But if incentives get out of whack, humans activate to behave in agency that abide to account them generally at the amount of others or even at their own amount down the road. Whatever changes we accomplish to our bloom affliction arrangement (and there’s consistently added than one way to derma a cat), we accept to be abiding to adjust incentives so that the behavior that after-effects in anniversary allotment of the arrangement contributes to its sustainability rather than its ruin.
Here afresh is a arbitrary of what I accede the best recommendations I’ve arise beyond to abode the problems I’ve categorical above:
1. Change the way allowance companies anticipate about accomplishing business. Allowance companies accept the aforementioned ambition as all added businesses: aerate profits. And if a bloom allowance aggregation is about traded and in your 401k portfolio, you wish them to aerate profits, too. Unfortunately, the best way for them to do this is to abjure their casework to the absolute barter who pay for them. It’s harder for them to advance accident (the action of any allowance company) about to say, a car allowance company, because far added humans accomplish bloom allowance claims than car allowance claims. It would seem, therefore, from a customer perspective, the clandestine bloom allowance archetypal is fundamentally flawed. We allegation to actualize a bridle for bloom allowance companies to abjure claims (or, conversely, an added allurement for them to pay them). Allowing and auspicious aross-state allowance antagonism would at atomic partially appoint chargeless bazaar armament to drive down allowance premiums as able-bodied as accessible up new markets to bounded allowance companies, benefiting both allowance consumers and providers. With their barter now armed with the all-important adeptness to go elsewhere, bloom allowance companies adeptness arise to appearance the superior with which they in fact accommodate account to their barter (ie, the paying out of claims) as a way to absorb and abound their business. For this to work, monopolies or near-monopolies accept to be disbanded or at the absolute atomic discouraged. Even if it does work, however, government will apparently still accept to bind adjustment of the bloom allowance industry to ensure some of the abhorrent abuses that are traveling on now stop (for example, allowance companies shouldn’t be accustomed to coat consumers into sub-groups based on age and admission premiums based on an earlier group’s college boilerplate accident of affliction because advantageous earlier consumers afresh end up accepting penalized for their age rather than their behaviors). Karl Denninger suggests some arresting account in a column on his blog about acute allowance companies to action identical ante to businesses and individuals as able-bodied as creating a binding “open enrollment” aeon in which participants could abandoned opt in or out of a plan on a annual basis. This would anticipate individuals from abandoned affairs allowance if they got sick, eliminating the adverse alternative botheration that’s apprenticed allowance companies to abjure transaction for above-mentioned conditions. I would add that, about acceding ante to bloom affliction providers are bent in the approaching (again, an complete column unto itself), all bloom allowance plans, whether clandestine or public, accept to balance bloom affliction providers by an according allotment to annihilate the actuality of “good” and “bad” allowance that’s currently amenable for affective hospitals and doctors to complete or even abjure account to the poor and which may be amenable for the aforementioned affair occurring to the aged in the approaching (Medicare reimburses abandoned hardly bigger than Medicaid). Finally, apropos the abstraction of a “public option” allowance plan accessible to all, I anguish that if it’s decidedly cheaper than clandestine options while accouterment near-equal allowances the complete country will blitz to it en masse, active clandestine allowance companies out of business and banishment us all to angel one another’s bloom affliction with college taxes and beneath choices; yet at the aforementioned time if the bulk to the customer of a “public option” charcoal commensurable to clandestine options, the absolute humans it’s meant to advice will not be able to acquiesce it.
2. Actuate the citizenry to appoint in convalescent lifestyles that accept been accurate to anticipate disease. Prevention of ache apparently saves money, admitting some accept argued that active best increases the likelihood of developing diseases that wouldn’t accept contrarily occurred, arch to the all-embracing burning of added bloom affliction dollars (though even if that’s true, those added years of activity would be advised by a lot of admired abundant to absolve the added cost. Afterwards all, the able purpose of bloom affliction is to advance the superior and abundance of life, not save association money. Let’s not put the barrow afore the horse). However, the abstraction of preventing a potentially bad aftereffect ancient in the approaching is abandoned abominably affective psychologically, answer why so abounding humans accept so abundant agitation accepting themselves to exercise, eat right, lose weight, stop smoking, etc. The abstraction of financially advantageous adorable behavior and/or financially backbreaking abominable behavior is awful controversial. Admitting I anguish this affectionate of action risks the assuming of behavior that may affect on basal freedoms if taken too far, I’m not adjoin cerebration creatively about how we could advantage stronger motivational armament to advice humans accomplish bloom goals they themselves wish to achieve. Afterwards all, a lot of adipose humans wish to lose weight. A lot of smokers wish to quit. They adeptness be added acknowledged if they could acquisition added able motivation.
3. Decrease overutilization of bloom affliction assets by doctors. I’m in acceding with Gawande that award agency to get doctors to stop overutilizing bloom affliction assets is a aces ambition that will decidedly rein in costs, that it will crave a alertness to experiment, and that it will crop time. Further, I accede that absorption abandoned on who pays for our bloom affliction (whether the accessible or clandestine sectors) will abort to abode the affair adequately. But how absolutely can we actuate doctors, whose pens are amenable for a lot of of the money spent on bloom affliction in this country, to focus on what’s absolutely best for their patients? The abstraction that alien bodies—whether allowance companies or government panels—could be acclimated to set standards of affliction doctors accept to chase in adjustment to ascendancy costs strikes me as ludicrous. Such bodies accept neither the training nor cardinal affair for patients’ abundance to be trusted to accomplish those judgments. Why abroad do we accept doctors if not to administer their adeptness to administer nuanced approaches to circuitous situations? As continued as they plan in a arrangement chargeless of incentives that attempt with their assignment to their patients, they abide in the best position to accomplish decisions about what tests and treatments are account a accustomed patient’s consideration, as continued as they’re accurate to abstain brash paternalism (refusing to admission a arch CT for a cephalalgia adeptness be overconfidently paternalistic; abnegation to action chemotherapy for a algid isn’t). So conceivably we should annihilate any banking allurement doctors accept to affliction about annihilation but their patients’ welfare, acceptation doctors’ salaries should be broken from the bulk of surgeries they accomplish and the bulk of tests they order, and should instead be set by bazaar forces. This archetypal already exists in bookish bloom affliction centers and hasn’t seemed to advance base affliction if doctors feel they’re accepting paid fairly. Doctors allegation to acquire a adequate active to atone for the years of training and massive amounts of debt they amass, but no banking allurement for practicing added anesthetic should be accustomed to attach itself to that adequate living.
4. Decrease overutilization of bloom affliction assets by patients. This, it seems to me, requires at atomic three interventions:
* Authoritative accessible the appropriate assets for the appropriate problems (so that patients aren’t traveling to the ER for colds, for example, but rather to their primary affliction physicians). This would crave hitting the “sweet spot” with account to the bulk of primary affliction physicians, best at front-line gatekeeping, not of bloom affliction spending as in the old HMO model, but of triage and treatment. It would aswell crave a recalculating of acceding levels for primary affliction casework about to specialty casework to animate added medical acceptance to go into primary affliction (the about-face of the alarming trend we’ve been seeing for the endure decade).
* A massive accomplishment to admission the bloom articulacy of the accepted accessible to advance its adeptness to triage its own complaints (so patients don’t in fact go anywhere for colds or appeal MRIs of their backs if their trusted physicians tells them it’s just a strain). This adeptness be best able through a alternation of educational programs (though accustomed that no one in the clandestine area has an allurement to armamentarium such programs, it adeptness in fact be one of the few things the government should—we’d just allegation to abstraction and analyze altered educational programs and methods to see which, if any, abate accidental accommodating appliance afterwards deepening outcomes and aftereffect in added bloom affliction accumulation than they cost).
* Redesigning allowance affairs to accomplish patients in some way added financially accountable for their bloom affliction choices. We can’t accept humans traveling broke due to illness, nor do we wish humans to underutilize bloom affliction assets (avoiding the ER if they accept chest pain, for example), but neither can we abide to abutment a arrangement in which patients are in fact motivated to overutilize resources, as the accepted “pre-pay for everything” archetypal does.
Given the astronomic complication of the bloom affliction system, no individual column could possibly abode every botheration that needs to be fixed. Cogent issues not aloft in this commodity cover the challenges associated with ascent biologic costs, direct-to-consumer business of drugs, end-of-life care, sky-rocketing abuse allowance costs, the abridgement of bulk accuracy that enables hospitals to paradoxically allegation the uninsured added than the insured for the aforementioned care, extending bloom affliction allowance advantage to those who still don’t accept it, convalescent authoritative ability to abate costs, the accomplishing of cyberbanking medical annal to abate medical error, the banking accountability of businesses accepting appropriate to accommodate their advisers with bloom insurance, and abomination reform. All are greatly interdependent, continuing calm like the accepted abode of cards. To appear to any one is to affect them all, which is why hasty through bloom affliction ameliorate afterwards accurate ambition risks adventitious and potentially adverse consequences. Change does allegation to come, but if we don’t acquiesce ourselves time to anticipate through the problems acutely and cleverly and to apparatus solutions in a abstinent fashion, we accident bringing down that abode of cards rather than cementing it.
» Read more: A Prescription For the Health Care Crisis